WARRENTON — One person was killed and five people injured Thursday morning when a tractor-trailer ran a stop sign, hit a pickup truck, then slammed into a house in Warren County.

Two adults and two children -- ages 4 and 7 -- in the house were slightly injured when the truck crashed into the living room and and kitchen area in the back of the house. The pickup driver, Richard Hargrove, was killed, said Warren County Sheriff Johnny Williams. A passenger in the pickup was seriously injured.

Authorities said a flatbed tractor-trailer truck traveling north on Warren Plains Road ran a stop sign at U.S. 158 Bypass, striking Hargrove's pickup truck on the bypass.

The tractor-trailer truck continued north, veering off the road and striking a house about 100 yards from the intersection.

"I noticed the back of the house, and I heard children screaming," said neighbor Steve Gustkey.

The accident happened about 7:40 a.m., about two miles north of Warrenton.

Williams said the two-story wood frame house was destroyed after the truck ran through the back, tore through bedrooms and stopped at the edge of the kitchen.

``In my opinion it's a total loss,'' he said.