Michael Bailey died late Friday morning at Duke University Hospital, police said.
Charges against two of the men in the case, Dyshaun Johnson and Dominique Arrington, were upgraded to murder.
Earlier in the day Friday, a judge refused to lower the bond of four suspects involved in two shootings and the chase in Durham.
The judge kept the bond set at $100,000 for the men who police say shot at a group of girls and later shot and killed a man before leading Durham police on a 20-minute chase.
Police say the two men fired several shots at Bailey and took off in a sport utility vehicle with three other people.
The suspects ended up leading police on a 20-minute chase. The pursuit ended when the SUV hit a fence.
Korri Maurice Harris, 19, of Burch Avenue, Dyshaun Tyreek Johnson, 16, of Exum Street, Dezmond Ramario Williams, 20, of Meriwether Drive, Dominique Lamont Arrington, 16, of Carroll Street and Michael Anthony Hudson Jr., 19, of Gillette Street were all charged with possession of marijuana and cocaine with the intent to manufacture, sell or deliver, possession of drug paraphernalia and resisting, delaying and obstructing an officer.
Williams was also charged with felony speeding to elude law enforcement officers and careless and reckless driving, and Arrington was also arrested on an old warrant charging him with assault inflicting serious injury.
Williams was out on bond when the chase happened, authorities said. Williams was released only eight days before the chase.
Johnson was already on probation for drug charges.
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