The men, both in their early 20s, were shot in the back parking lot at Hampton Crossings Apartments, 405 Pilot St., shortly before 6 p.m., police said.
Both victims were transported to Duke University Hospital. An update on their conditions was not available.
More details, including the identities of the victims, haven't been released.
Anyone with information is asked to call the Durham Police Department at 919-560-4440 or Crime Stoppers at 919-683-1200.