Officers operated radar guns for eight hours along the 12-mile Cary Parkway as part of Operation Reducing Aggressive Driving and Recklessness, or RADAR.
Police issued more than 60 speeding tickets. The speed limit is 45 mph, and police clocked speeds up to 66 mph.
Police said they receive numerous complaints about speeders and that the crackdown is an effort to make the roads safer for other drivers, pedestrians and bicyclists.
"This one-day enforcement blitz isn't about ticketing. It's about educating drivers and improving the safety of all of us who use the road," Lt. Tracey Barker said.
Last month, a young couple died in a car crash on Cary Parkway after their car was struck by a driver going about 67 mph.
"That was a very tragic situation," Barker said.
With RADAR, Cary police hope to prevent another fatal accident and encourage drivers to slow down.
In 2011, Cary police issued 3,801 speeding tickets, including 206 on or near Cary Parkway.