The tractor-trailer was traveling northbound when a military vehicle it was hauling hit the underside of the bridge, near exit 72, just before 6 p.m., troopers said.
The military vehicle broke apart from the impact of hitting the bridge, sending metal flying across the interstate.
A Subaru struck a guardrail after being hit with flying debris, troopers said. Paramedics transported a Canadian couple – Helen and Richard Turle – to Betsey Johnson Memorial Hospital for treatment. Both were expected to be treated and released.
Two other vehicles were damaged by flying debris, troopers said. The drivers and passengers of those cars were not seriously injured.
Traffic was backed up for over an hour while wreckage was cleared off the interstate.