Natasha Dixon-Parker, 39, is believed to be suffering from dementia or some other cognitive impairment.
Parker, whose nickname is "Pecan," is described as a black woman standing about 5 feet 6 inches and weighing about 160 pounds. She has black hair and brown eyes, as well as a scar over her left eye. She is also missing two front teeth.
A photo was not immediately available.
Parker was last seen Sunday at 3659 Raleigh Road in Henderson and was wearing a white blouse with a gold pen stripe and brown pants, authorities said.
She might have been going to Dabney Drive or Water Street in Henderson, authorities said.
Anyone with information about Parker should call the Vance County Sheriff's Office at 252-738-2200.
Developed in 2007, Silver Alert is a system to quickly notify the public about missing endangered adults who suffer from dementia or other cognitive impairments, such as Alzheimer's disease.
It also allows caregivers and nursing homes to report a person missing. In the past, only a family member could report an adult missing.