Shaleta Nichole Bridges, 32, is believed to be suffering from dementia or some other cognitive impairment.
Bridges is black, stands 5 feet 9 inches tall and weighs approximately 198 pounds, Durham police said.
She was last seen wearing a flowered shirt, blue jeans, and her long black hair pulled back in a pony tail. She also has a tattoo on her chest and a scar on both her right leg and right arm.
Bridges was last seen at a group home on Atterbury Lane in Durham, authorities said. It was not known where she might be headed.
Anyone with information about Bridges should call the Durham Police Department at 919-560-4427.
Developed in 2007, Silver Alert is a system to quickly notify the public about missing endangered adults who suffer from dementia or other cognitive impairments, such as Alzheimer's disease.
It also allows caregivers and nursing homes to report a person missing. In the past, only a family member could report an adult missing.