Troopers said a westbound car crossed the center line in the 5700 block of Poplar Springs Church Road around 4 p.m. and struck an eastbound Ford pickup truck.
Jonathon Stone was partially ejected from the front passenger seat of the pickup, troopers said. He died of his injuries.
The pickup driver was flown to UNC Hospitals in Chapel Hill. His brother, who was in the back seat, was treated and released from a local hospital.
The car driver was taken to Central Carolina Hospital, then transported by to UNC Hospitals.
The identities of those injured in the wreck haven't been released. An update on their conditions wasn't available.
Troopers said that the cause of the wreck remains under investigation, but alcohol and speed were not factors.
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