Dennis Robertson, 47, died in his bedroom on Charles Street in Henderson. Three apartments were damaged by the fire.
Investigators say the fire, which started in a mattress, was likely caused by a lit cigarette.
Near Franklinton, firefighters were able to extinguish a fire, but were unable to prevent a tragedy.
Ora Byrd, 73, was killed in the fire which happened around 3 a.m. Wednesday on Beechwood Drive.
The Franklin County Sheriff's Department says the fire started in a chair that is powered by electricity.
The victim's husband had been awakened after smelling smoke. He managed to escape.
Monday, afire in Oxfordclaimed the lives of four elderly family members.
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