The accident happened on the northbound side of the interstate when a car with Pennsylvania plates ran into the center median and the driver apparently over-corrected to the right and the car rolled over, troopers said.
The crash was just north of Benson.
Helicopters flew one of the injured people to Pitt Memorial Hospital in Greenville and the other to UNC Hospitals in Chapel Hill, police said.
Troopers did not immediately release the identities of the victims.
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