The FBI and Chatham County law officers are searching for the men, who were armed.
They entered the Fidelity Bank in Moncure about 4 Friday afternoon.
They took the money and got away in a tan car.
Officials later found the car abandoned about a mile from the bank. It had been stolen in an earlier robbery.
Anyone with information on the suspects or the car is asked to call the FBI at 919-233-7701.