The Bulls took an early lead in the third, thanks to Paul Hoover's first of two homers. Hoover hit his second blast and fifth of the year in a four-run fifth, as Durham took a 5-0 lead.
Eric Munson capped a six-run sixth with a grand slam, his 25th homer, for an 11-0 advantage.
Delmon Young added a homer, his sixth, in the eighth.
Durham now has 198 homers this season with two games left. Buffalo, in 1998, was the last International League team to hit 200 homers in a season.
The Bulls Dewon Brazelton (2-2) battled through 5.2 innings to earn the win.
Charlotte left 16 runners on base and committed five errors.
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