Police said Kayla Radack, 16, crossed the center line on Rose of Sharon Road near Marywood Drive, hitting another car head-on just before 6 p.m.
The Riverside High School student was taken to Duke Medical Center, where she died Tuesday morning.
Beth Blevins Foster, the driver in the other car, is listed in serious condition.
A third vehicle was damaged when it went off the road to avoid colliding with Radack's car.
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