Officers responded to a shooting call just after 9 p.m. at 1212 Dawkins St. When they arrived, they found Timothy Deangelo McGhee, 24, dead inside the house.
Paul Anthony Noel Jr., 22, of 700 Morreene Road, was transported to Duke University Hospital with gunshot wounds. He died a short time later, police said.
Investigators said a person fired shots into the house, but weren't sure how many people were involved. At least three people were inside the house at the time of the shooting. No one else was injured.
No charges have been filed at this time.
This marks the second and third fatal shooting in Durham this year. Last year, the third fatality wasn't until March.
"We have too many guns, too many drugs and too many thugs willing to use them to advance their own sordid activities," said Durham City Councilman Eugene Brown.
Rodney Twitty and his mother, Tamithal Picket, said they heard the gunshots down the street.
"Well, I ducked," Rodney said. "I was so scared to go to the bus stop."
Picket said she walked her son to the bus, "just to make sure" he was safe.
Anyone with information about the shooting is asked to call Investigator Soucie at 919-560-4440, extension 29337, or Crime Stoppers at 919-683-1200. Crime Stoppers pays cash rewards for information leading to arrests in felony cases and callers never have to identify themselves.