The flight, which will leave RDU daily at 5:05 PM, is the first expansion for JetBlue since it launched four daily flights to New York's John F. Kennedy International Airport in July.
JetBlue's RDU service is off to a strong start, according to airline spokesperson Alison Eshelman.
"It's been great," she said. "We have full flights daily, hence the daily additional route to Boston."
JetBlue previously had announced its plans to add the Boston flight. It is the only expansion currently on tap.
"Right now we don't have anything planned," Eshelman said. "We watch how the routes are doing, and we obviously listen to our customers as well. (Expansion) is something we definitely don't rule out."
Fares on the RDU-Boston flight range from $94 to $209 one way, but introductory fares of $49 each way are available.
The Boston-to-RDU flight will leave at 2:30 PM daily.
JetBlue utilizes 100-seat Embraer 190 aircraft on the RDU flights. The airline now has 470 flights daily serving 47 destinations. It will add a flight to Cancun, Mexico, from JFK in November.
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