Officials said man entered the bank shortly after 9 a.m. and handed a teller a note demanding money. The note said the suspect had a gun, but no weapon was seen.
The man fled with an undisclosed amount of cash.
He was last seen getting into a gray Dodge Stratus with North Carolina license PRJ-4987. The car was parked in an apartment complex parking lot behind the bank.
The suspect is described as a white or Hispanic male in his 30s. He was approximately 5 feet 10 inches tall with a slender to medium build. He had a light mustache and curly, shoulder-length hair, according to police.
Anyone with information is asked to call the Durham Police Department's Criminal Investigations Division at 560-4440, CrimeStoppers at 683-1200, the FBI at 233-7701 or (704) 377-9200 or the N.C. Bankers' Association hotline at (800) 209-2293.
CrimeStoppers is offering a reward of up to $1,200 and the North Carolina Bankers' Association is offering a reward of up to $5,000 for information leading to an arrest.