Deanna Boone, a spokeswoman for the town, said the motorcycle was traveling north on Davis Drive when the southbound SUV turning left onto Waldo Rood Boulevard slammed into it.
The motorcyclist, Tomoichi Martin Cummings, 54, of 117 Ashwyn Court, was transported to Duke University Hospital, where he was pronounced dead.
Boone said an initial investigation of the wreck found that the SUV's driver, Doris Yates Upchurch, 80, of 2132 Carpenter Upchurch Road in Cary, was at fault.
Charges are pending.
It was unclear whether rain Tuesday morning was a factor in the wreck.
Davis Drive at Salem Church Road was closed for several hours as a result of the wreck.
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