Duke doctors drop 'smart bomb' on breast cancer
Duke Cancer Institute doctors have successfully dropped the first "smart bomb" on breast cancer, using a drug to deliver a toxic payload to tumor cells while leaving healthy ones alone.Posted — Updated
In a key test involving nearly 1,000 women with a very advanced stage of the disease, the experimental treatment extended by several months the time women lived without their cancer getting worse, doctors planned to report Sunday at a cancer conference in Chicago.
More importantly, the treatment seems likely to improve survival, although it will take more time to know for sure. After two years, 65 percent of women who received it were still alive versus 47 percent of those in a comparison group given two standard cancer drugs.
That margin fell just short of the very strict criteria researchers set for stopping the study and declaring the new treatment a winner, and they hope the benefit becomes more clear with time. In fact, so many women on the new treatment are still alive that researchers cannot yet determine average survival for the group.
"The absolute difference is greater than one year in how long these people live," said the study's leader, Dr. Kimberly Blackwell, director of Duke's Breast Cancer Clinical Program. "This is a major step forward."
A warning to hopeful patients: The drug is still experimental, so it is not available for widespread use yet. Its backers hope it can reach the market within a year.
The treatment builds on Herceptin, the first gene-targeted therapy for breast cancer. It is used for about 20 percent of patients whose tumors overproduce a certain protein.
Researchers combined Herceptin with a chemotherapy so toxic that it can't be given by itself, plus a chemical to keep the two linked until they reach a cancer cell where the poison can be released to kill it.
This double weapon, called T-DM1, is the "smart bomb." It's actually not all that smart; Herceptin isn't a homing device, just a substance that binds to breast cancer cells once it encounters them.
"This is a more targeted way of delivering chemotherapy," Blackwell said. "It delivers the drug directly to the cancer cells, while avoiding cells that don't really need to receive chemotherapy, which keeps patients from getting sick."
Doctors tested T-DM1 in 991 women with widely spread breast cancer that was getting worse despite treatment with chemotherapy and ordinary Herceptin. They were given either T-DM1 infusions every three weeks or infusions of Xeloda plus daily Tykerb pills, the only other treatments approved for such cases.
The median time until cancer got worse was nearly 10 months in the women given T-DM1 versus just over six months for the others. That is about the same magnitude of benefit initially seen with Herceptin, which later proved to improve overall survival, too, Blackwell said.
T-DM1 caused fewer side effects than the other drugs did. Some women on T-DM1 had signs of liver damage and low levels of factors that help blood clot, but most did not have the usual problems of chemotherapy.
"People don't lose their hair. They don't throw up. They don't need nausea medicines. They don't need transfusions," said Blackwell, who has consulted in the past for Genentech, the study's sponsor.
"The data are pretty compelling," said Dr. Michael Link, a pediatric cancer specialist at Stanford University who is president of the American Society of Clinical Oncology, the group hosting the Chicago conference where the results were being presented.
"It's sort of a smart bomb kind of therapy, a poison delivered to the tumor ... and not a lot of other collateral damage to other organs," he said.
Dr. Louis Weiner, director of Georgetown Lombardi Comprehensive Cancer Center, said the results strongly suggest T-DM1 improves survival. It delivers more drug directly to tumors with less side effects, "a clear advance," he said.
Denise Davis, 51, a customer service representative at a propane company, was diagnosed three years ago with breast cancer that had spread to her liver and bones. Since February 2011, the Lynchburg, Va., woman has traveled two hours to Duke every three weeks to get infusions of T-DM1.
"I call it 'Herceptin-plus,'" she said. Scans every six weeks show "everything is still shrinking or stable," she said. "Right now, I'm feeling pretty good about it. The only way I'd feel a little better is if it took care of everything, but I'll take what I can get."
The study will form the basis for Genentech, part of the Swiss company Roche, to seek approval later this year to sell the drug in Europe and the United States. Another company, ImmunoGen Inc., made the technology combining the drugs.
Genentech says the price of T-DM1 has not been determined. Herceptin costs more than $4,000 a month plus whatever doctors charge to infuse it. Herceptin's U.S. patent doesn't expire until 2019.
Cancer conference: http://www.cancer.net
American Cancer Society: http://www.cancer.org
Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP
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