A statement shared on the raspy-voiced rapper's official Instagram account said he was "putting family and sobriety first."
"DMX has checked himself into a rehab facility," the 48-year-old's team wrote alongside a picture of him.
"He apologizes for his cancelled shows and thanks his fans for their continued support."
The "Party Up (Up In Here)" hitmaker had been due to perform at a Three 6 Mafia reunion concert on Saturday night in Memphis and day 2 of the Rolling Loud festival in New York on Sunday.
The hip hop star -- whose real name is Earl Simmons -- has struggled with substance abuse for years and has been arrested on multiple charges, including drug possession and animal cruelty.
In 2010, he was sentenced to a year in prison for violating the terms of his probation.
In 2011, the father of 15 said his children helped him beat his addiction to cocaine, saying: "I have to drive them in the right direction, so I let the cocaine go."
In January this year, DMX was released from prison after serving a year behind bars for tax fraud.
According to federal prosecutors in New York, he concocted a multi-year scheme to hide millions in income from the IRS and skirt $1.7 million in existing tax liabilities.
Following his release he embarked on a 32-date tour to mark the 20th anniversary of his debut LP, "It's Dark and Hell is Hot."
CNN has reached out to DMX's representatives for comment.
Copyright 2024 by Cable News Network, Inc., a Time Warner Company. All rights reserved.