Name: Full interview: Johnson & Johnson research exec talks about coronavirus vaccine progress
Uploaded: 2020-09-23T19:30:26-0400
Duration: 311234
Description: WRAL's David Crabtree spoke exclusively with Dr. Mathai Mammen of Johnson & Johnson about the company's efforts to develop a coronavirus vaccine.

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WRAL's David Crabtree spoke exclusively with Dr. Mathai Mammen of Johnson & Johnson about the company's efforts to develop a coronavirus vaccine.

Dr MTI. Mammon is the global head of research and development in Johnson and Johnson. Doctor, thanks for joining us this evening. Thanks for having me. What makes the Johnson and Johnson vaccine candidate stand out in your mind from the rest it zits based on really good science what we did in our cases. We developed a large number of vaccines that we put through rigorous testing pre clinically and selected what we believed would be the very best one based on pre clinical studies. Put it into humans back at the end of July and found that it did indeed have just excellent ability to induce a robust immune response. If we connect that back to our pre clinical data, we project very high efficacy from that immune response. So that's number one and number two. We believe we can get that robust immune response with a single dose rather than requiring two doses. And number three. It's in a platform that's been in about 100,000 or more people. It's called had 26 as a platform, and that gives us great confidence in the platforms safety primarily and and finally that platform when we've we've had experiences with it before is very stable to the environment where some of the other vaccines you need to keep them in extremely cold temperatures like minus 80 degrees Celsius. Ours weaken store in the refrigerator, you know, and you talk about the single dose. Uh, that is huge when it comes to distribution being able to get the public in Onley one time, do you sense that will make it even mawr? Ah, people would be more open. Two thoughts of becoming vaccinated if they know they only have toe. Have this happened one time? Yeah, I think we're in a very unprecedented time. Has been, has been said numerous times But I think the concept of mass vaccination hundreds of millions, billions of people where they have the logistical challenge of of coming in, others keeping track of whether they've been vaccinated coming back. This is something that I don't think the mass of humanity knows how to do very effectively at the moment for multi dose regimens. So I think you're exactly right. The single dose is gonna be a big advantage. That said, though I have to say we're also going to study this vaccine in a two dose regimen later this year, primarily based in Europe and a little bit in the United States, as well as a belt and suspenders approach. But I have confidence in the single dose regimen. You know, we have Moderna and fighter trials underway here in central North Carolina. Johnson and Johnson Clanton rolls 60,000 people. What type of candidates are you looking for? We're looking for all kinds. So initially they will be in that 18 to 75 or older range. Um, and will will look to expand to special populations. All ethnicities on will eventually be ableto expand into the pediatric population, the Children as well. But right now it's focused on 18 and older. Doctor, I'm curious as a scientist and researcher, and you've been at this a long time when you and your team saw those promising results come in as they have. What was that moment like when you first saw that and thought, Oh my gosh, we may be very closely. I have to say the most overwhelming thought. I think among the team was great relief because it was anticipated for months, right? This was something that the team's been working all the time like literally in the daytime evening weekends. It's in all the time thing. There are people that have worked literally every day for a long, long time. And so you get your hopes up. As you watch the pre clinical data build, you gain confidence that you can manufacture this vaccine. You have problems along the way that you've somehow solved. And then So it all hangs on this immunogen ISS ity data that's coming out of early clinical development and safety. And so that both safety and ImmunoGen Isett e was so strong was on overwhelming sense of relief. Well, we are grateful for your research. We and as the public are hoping that this is the breakthrough. We've been looking forward, no matter who, the company who the researchers are the fact that humanity has the possibility of seeing our way through this pandemic sooner rather than later. Dr. MTI Mammon with Johnson and Johnson, head of global head of research and development, were deeply appreciative of your time and your work. Thank you for having me. Thank you, sir. His youth possible

David Crabtree

Jason O. Boyd

Full interview: Johnson & Johnson research exec talks about coronavirus vaccine progress

David Crabtree interview with Johnson & Johnson executive

Johnson & Johnson,coronavirus,coronavirus medicine,coronavirus vaccine,vaccination

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<p>Good morning. I'm meteorologist Elizabeth Gardner. We have a gorgeous day and our forecast, our temperatures are pleasantly cool this morning, skies are clear and our wind is mostly calm. Now. There may be some gusts that happened later on this afternoon. We could be gusting 15 to almost 20 MPH in the middle of the day and then we'll see the wind starting to die down. It's not going to be anything that causes you any real issues, but just a touch on the breezy side. Midday. Our temperatures heading out the door this morning are chilly anywhere from mid forties to mid f depending on where you are. And it's going to be a lovely day today. Lunch outside. Absolutely. If I could put some exclamation points on this, I would almost 70 at lunchtime humidity, low, lots of sunshine, take advantage of this absolute gorgeous afternoon for lunch outside or whatever it is that you can do our highs mid afternoon, 74 in Raleigh, 72 in Durham and 78 in Fayetteville. So such a pretty day. Uh, lots of things to uh to do. It's a very busy time time of year lots of festivals and things. And I imagine with game three, the hurricanes versus the Islanders, there will be a lot of people out at watch parties, temperatures before the game will be dropping to around 60 then on into the upper fifties, by the time the game is over, cool, beautiful sunny conditions and low humidity. Look at that low humidity. It's in the fifties all the way up through Saturday and Sunday. But then on Monday it starts to climb up to 60 it gets into the sixties. That's when you start to notice it. You know, some days you're like, it feels humid. So we're going to start to feel it. It's not going to be overwhelming, you know, not looking at steamy or tropical conditions, but it will start to creep up as we get into the weekend. Look at the temperature change that we're going to see. You see the blue color contours, that's where temperatures are either below normal or close to normal. And then once we get into Sunday and much of next week, we're going to see temperatures climbing above normal. So we're talking about some eighties. Our normal highs are in the mid seventies and would be pretty close to that through Saturday. Then we start to climb into the eighties and we have the potential on Tuesday to be close to a record. The uh high temperature 88 the record nine back in 1906. So getting close to record territory. By the, uh, beginning of next week, it stays mainly dry. The only real chance of any rain we have is a tiny chance on Tuesday. Just a 20% chance. So we have a very dry period in our seven day forecast.</p>

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Nightly N.C. Education Lottery drawings during the 11 p.m. News.

Good evening. I'm Gayle Hurd. Welcome to tonight's drawings for Wednesday, April 24th, 2024. Well, let's get started tonight with our Carolina pick three. Our first winning number is a seven. Our second number is six and the third number tonight is a nine and our pick three. Fireball number is six. Joining me for tonight's show is our auditor from mcconnell and Jones L LP. Now let's move to the Carolina pick four. Good luck. Everyone who's that first winning pick four number, it's zero. Our second number is a nine. Third number tonight is three and our fourth number is one in our pick for fireball number. There it is. It's three. Again, we're turning now to the Carolina cash five and no one was the top prize tonight. Tomorrow's top prize is estimated at $620,000. Good luck. Everyone here's their first win in cash five number. It's a 29. Our second number, it's 37 3rd number tonight. It's 34. Our fourth number is lucky 13 and the final number in our cash five this evening is 12. The North Carolina Education lottery has contributed over $10 billion to education. Get your winning numbers right here every night on your exclusive station for the North Carolina Education lottery. Thanks for playing. Have a great night.

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Ball. Good evening, Ruan, I Randy trainer. Tonight. We have another life changing jackpot. It's worth an estimated $130.2 million. So, get your tickets ready here. Come, tonight's winning numbers. Let's start things off this evening with the number 26. Right after that America. We have the number two and congratulations to Gina Magnum from North Carolina. She won $50,000 playing powerball. All right, the rest of your winning numbers tonight 20 47. And let's round it out tonight with the number 22 and tonight 20 powerball number, that's gonna be 21 and your power play multiplayer is four. Let's take another look at tonight's winning numbers. We'll see you back here on Saturday night. It's time to play America's favorite.

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Daytime Pick 3 and Pick 4 drawings are held at 3 p.m. daily. They can be seen as live or on-demand video.

Good afternoon. I'm Luis Fernandez. Welcome to this afternoon's drawings for Wednesday, April 24th, 2024. Let's get started with Carolina pick three. The first pick three number is two, second is eight and the third is eight and our pick three fireball number is five. Join me for this afternoon's drawing is our auditor for mcconnell LP. Now let's move to Carolina pick four. The first pick four, number is five. The second is one, the third is three and the fourth is zero and our pick four. Fireball number is five. The North Carolina Education lottery has contributed over $10 billion to education and thanks for your support.

Daytime Pick 3 and Pick 4 Drawing

Brian Shrader flies over the site of a plane crash at Raleigh-Durham International Airport approximately three hours after the accident.

Seen some activity just in the past 10 minutes or so. I want to take you outside Sky five right now for a live look at the scene. We saw a van being escorted to the runway there and someone got out and now there appears to be a really careful inspection of the debris going on. So we're working to confirm if that may be the NTSB investigation team arriving at the scene. Let's zoom out and give you some about where this is. There are two main runways at RDU International and this is in the grassy field next to the runway that mostly serves terminal one on the east side of the airport, that runway remains closed while this investigation continues at the top of your screen. That is the other main runway that serves terminal two, mostly that runway is open. So we have two things going on here that could affect your flights for the rest of the day and maybe even into tomorrow, the airport takeoff and landing capacity is roughly reduced by half because they are only working with one runway. And if you have a flight coming out of terminal one, maybe Southwest, you're going to have to take that crossover all the way out to that other runway. It's going to add a lot of extra time.

Sky 5 flies over RDU plane crash 3 hours later 

A UNC Health physician and pilot were taken to the hospital Wednesday after a small plane crashed at Raleigh-Durham International Airport (RDU).


Sky 5 flies over plane crash at RDU

RDU Airport Authority gives an update on a plane crash that sent a physician and pilot to the hospital. The crash occurred Wednesday morning on a flight that took off from Wilmington.

<p>Landguth first, I want to extend my thoughts to those affected by this morning's aircraft accident and thank our first responders for their quick action to respond. The airport authority and its mutual aid partners responded to an aircraft accident at RDU involving a general aviation aircraft. The accident occurred at approximately 10:10 a.m. in the grass next to runway five, right 23 left. The flight was arriving from Wilmington, North Carolina. The A the aircraft is owned by medical Air Inc and operated by UN C air operations. The aircraft had two people on board, one pilot and one passenger. Both were transported to area hospitals. The federal A Bush administration issued a ground stop that was lifted at approximately 1130 this morning. The Federal Aviation Administration and the National Transportation Safety Board have both been notified. The National Transportation Safety Board is en route and expected to arrive within the next hour at which time we will conduct an accident investigation. Rdu's runway five left 23 right reopened to departing and arriving aircraft around 11:30 a.m. this morning. Are you experiencing approximately 70 delays and several arriving flights were diverted to other airports? Until ground stock was lifted, travelers should contact their airline for the latest updates regarding the flight status. And of course questions about the identity and condition of the pilot and passenger should be directed to UN C health. And at this time I'll try to answer any questions. You may have, uh, the one, any other accidents in, in the past. I'm not familiar with any other accidents have occurred with that operation. I don't know, uh, that's the role of the National Transportation Safety Board. They'll actually come in and do the investigation. Uh, and at some point in the future, they write up a report and determine what the cause of the accident was. You know, that there was no notification to the airport authority or to the FAA uh about any type of emergency on board. Do we have a guy? We don't, all we know that we've got them out of the airplane and we've got them transported to local hospitals. We know situations like this and delays have a ripple effect on, you know, flights. Do you have any idea what type of impact we'll see here in our view and for not sure, but what we're going to encourage everybody to do is reach out to your airlines. We'll be able to give you real time information about the impact of your particular flight. Ok. I believe some of them went to Greensboro and I think a couple went to Charlotte as well. What, what to be impacted due to the NTSD. Say that one more time at this point in time, what we call the west side of our airport is now open the investigation they'll conduct will all be on the east side. So at this point, we are anticipating normal operations returning to normal operations from this point forward. I don't think that anything that they're doing regarding the investigation or where they would have to investigate would have any impact to the west side of the airport. No, the aircraft is still on the airfield itself. It's on the east side of the field. So terminal one that runways the east side of the field, that's where the debris field actually sits, the west side of the field is open and operational and safe to operate. Not that I'm aware of in operations for you throughout this event today. What was your main concern concerning the passengers that were in the internals? Right. I think our primary focus when, when that accident occurred were the two people sitting in that aircraft? Our primary mission is to make sure we can get to them and try to rescue them and try to make sure that we can get them in a safe condition as fast as we possibly can. Uh secondarily is trying to figure out then how we recover and get our operations back up and running. Mhm. How does that affect? What goes on term? Yeah, so great. Question. So the team has figured out a way to get all the aircraft they're gonna operate at terminal one. Your Southwest develops. Uh We've got a crossover taxi way that we can actually get them through our general aviation aircraft. We've got a crossover taxiway, we can get them to. But the rest of the uh accident scene is actually kind of isolated and closed and locked off. Yeah, you're terminal one at this point in time. Once they can get back on their schedule, it's going to be a normal operations. All right. Thank you guys. All right. Thank you. Grab your phone, right.</p>

Full interview: Johnson & Johnson research exec talks about coronavirus vaccine progress

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