AT HOME. THOSE STORIES AND A LOT MORE BEGINNING AT THE TOP OF THE HOUR. >>> COVID-19 VACCINES ARE ON THE WAY TO PEOPLE ALL OVER THE WORLD. DUKE EXPERTS SAY WITHIN A YEAR OR SO LIFE MAY ONCE AGAIN HAVE SOME SENSE OF NORMALCY. WE CLAIM THE CHALLENGES THEY WILL TAKE TO GET AN EFFECTIVE VACCINE DISTRIBUTED TO EVERYONE. >> Reporter: THE LONG ANTICIPATED DEFENSE IN THE FIGHT AGAINST COVID-19 IS ALMOST HERE. >> WE ARE STARTING TO SEE SOME LIGHT IN THIS TUNNEL. >> Reporter: AFTER SEVERAL PROMISING TRIALS, MANUFACTURERS AND GOVERNMENTS ARE PREPARING TO VACCINATE BILLIONS OF PEOPLE IN THE NEXT YEAR. >> WHENEVER YOU DO SOMETHING OF THIS SIZE THERE'S PROBABLY GOING TO BE SOME SETBACKS ALONG THE WAY, BATCHES THAT DON'T MEET QUALITY CONTROL. >> Reporter: DUKE EXPERTS ARE TAKING A HARD LOOK AT THOSE CHALLENGES THAT THE WORLD WILL FACE DURING THE INITIAL ROLLOUT. >> RICH NATIONS ARE HOARDING THE VACCINE, WE ALL KNOW NOW ABOUT THE PFIZER AND MODERNA VACCINE, OVER 80 PERCENT OF ALL DOSES OF THOSE TWO VACCINES HAVE ALREADY BEEN PURCHASED BY RICH NATIONS. >> Reporter: CONCERNS ARE GROWING OVER HOW THE VACCINE WILL DID BE DISTRIBUTED TO LOW INCOME COUNTRIES AND IN AMERICA, INEQUITIES IN HEALTHCARE, RACIAL DISPARITY AND ASSESS ABILITY IN RURAL COMMUNITIES REMAIN A TOP ISSUE. >> WE ARE GOING TO HAVE TO BE PREPARED TO SOME BUT THOSE AREAS AND PROVIDE PORTABLE TYPES OF COOLING DEVICES TO GET VACCINES DISTRIBUTED. >> Reporter: THE BIGGEST BARRIER HEALTH FOR NATIONALS WILL FACE IS VACCINE RESISTANCE AMONG THE PUBLIC SO WE ASKED A FEW PEOPLE ONLINE IF THEY PLAN TO TAKE THE COVID-19 VACCINE AT SOME POINT AND HERE ARE A FEW RESPONSES. >> NOT UNTIL IT'S PROVEN SAFE AND RELIABLE AND IMMEDIATELY I WANT THINGS BACK TO NORMAL ASAP. >> WHEN PEOPLE TALK ABOUT VACCINE HESITANCY WE NEED TO FIGURE OUT WHAT'S GOING ON. >> Reporter: ASIDE FROM FACING THESE HURDLES, EXPERTS STILL PREDICT TO SEE A LARGE NUMBER OF PEOPLE VACCINATED BY THE SECOND HALF OF 2021. >>> DUKE EXPERTS ALSO THE MENTION THE NEED TO BEGIN A