Covid-19 variants make reopening more dangerous, infectious disease expert says

Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota, said the B.1.1.7 variant has resulted in increased transmission in countries with vaccination efforts similar to the United States.

"Our only hope right now is that we as a country take this seriously and do whatever we can to limit transmission, as these other countries tried to do," he said during an event hosted by Axios.

"And, yet, at the same time I sit here and tell you we've never been more open as a country since the very first days of the pandemic."

Osterholm said efforts to reopen schools are "frustrating," as are recent guidelines that schools can maintain three feet of social distance as opposed to six feet.

"The transmission dynamics are going to change, and it won't be quite the same way that it was." Osterholm said. "We don't seem to care, in the sense that we're opening up everything at local, state, and even federal levels."

More governors relax restrictions

Since the start of the month, at least a dozen state leaders have eased Covid-19 restrictions.

On Tuesday, Indiana Gov. Eric Holcomb announced that starting April 6, the state's face-covering mandate will become a state mask advisory. Masks will remain mandatory in state buildings and facilities as well as at Covid-19 testing and vaccination sites, the governor said.

Also starting April 6, decisions about venue capacity will be in the hands of local officials, Holcomb said, and customers in restaurants, bars and nightclubs will no longer be required to be seated. Six feet of spacing between tables is still recommended, he added.

In Virginia, Gov. Ralph Northam announced Tuesday that starting April 1, both indoor and outdoor gathering limits will increase and certain sports and entertainment venues will be able to operate with additional capacity.

"While some capacity limits will be increased, we must all remember to stay vigilant and work together to protect ourselves, our loved ones, and our communities," he said in a statement.

Vaccination pace doubled in less than two months

In less than two months, the pace of vaccination in the US has doubled.

Almost 130.5 million Covid-19 vaccine doses have been administered, according to data published Wednesday by the Centers for Disease Control and Prevention. The CDC reported that 130,473,853 total doses have been administered -- about 77% of the 169,223,125 doses delivered.

That's nearly 2.3 million more doses reported administered since Tuesday, for a seven-day average of about 2.5 million doses per day.

A month ago, the seven-day average was about 1.5 million doses per day, according to a CNN analysis of CDC data. On January 29, the seven-day average was 1,253,815 doses per day.

Vaccine eligibility across the US

Nearly 26% of the population -- almost 85.5 million people -- has received at least one dose of vaccine, and 14% of the population -- more than 46 million people -- are fully vaccinated, CDC data shows. A third of adults and about 70% of seniors have received at least one dose.

More Americans are going out, poll shows

As more Americans are vaccinated, the number of people going out is also increasing, according to a poll from Axios-Ipsos published Tuesday.

Compared to a month ago, the number of people who have gone out to eat or visit friends and family are up 12 and 9 percentage points respectively, according to the poll -- which was conducted March 19 to 22 and was made up of 995 Americans 18 and older.

The number of people who believe that dining out poses a large risk to health and well-being has gone down to 23% compared to 33% a month ago.

Those who have visited friends or relatives -- 48% -- is the highest since October. Additionally, 54% have visited a non-grocery retail store -- the highest number since May.

Experts worry AstraZeneca confusion may lead to vaccine hesitancy

Meanwhile, AstraZeneca is soon expected to apply for emergency use authorization for its Covid-19 vaccine in the US. But some experts fear recent concerns over an announcement of its vaccine data could further contribute to hesitancy.

In a Monday news release, AstraZeneca said its vaccine showed 79% efficacy against symptomatic disease and 100% efficacy against severe disease and hospitalization in a new US-based clinical trial.

But the National Institute of Allergy and Infectious Diseases said in a statement Tuesday the independent board that reviews data from multiple vaccine candidates raised concerns about the company's announcement.

The board "expressed concern that AstraZeneca may have included outdated information from that trial, which may have provided an incomplete view of the efficacy data," the NIAID statement said.

Speaking on ABC's "Good Morning America" on Tuesday, Dr. Anthony Fauci said the AstraZeneca news release may have contained misleading information about its vaccine efficacy -- "an unforced error" that may create doubt about what is likely a good vaccine.

The data is "really quite good, but when they put it into the press release, it wasn't completely accurate," Fauci said.

AstraZeneca said in a statement it will "immediately engage with the independent data safety monitoring board (DSMB) to share our primary analysis with the most up to date efficacy data," adding that it intend to issue results of the primary analysis within 48 hours.

One expert says she worries this may hinder confidence in the vaccines among Americans.

"I am very concerned because there is already so much misinformation and disinformation out there," emergency physician Dr. Leana Wen told CNN on Tuesday. "With this amount of public scrutiny, I think every company really should be aiming for full transparency and accountability and we really need to understand what happened here."

"AstraZeneca owes us an explanation," she added.

Covid cases dropping fastest among seniors, CDC says

Cases of Covid-19, as well as hospitalizations and deaths are dropping fastest among seniors in the US, a CNN analysis shows.

The 65 and older population has seen a larger decline in case rates, death rates and hospitalizations than any other age group, and they're accounting for a smaller share of total hospitalizations than they were a few months ago, according to the analysis of data from the CDC.

Among people 65 and older, weekly hospitalizations have been steadily declining since the start of the year, dropping 83% over nine weeks between early January and mid-March, CDC data shows.

More than half of hospitalizations were among people 65 and older in early January, but that had dropped to about 37% by mid-March.

Hospitalization data from the CDC's COVID-NET surveillance system is preliminary.

Additional data tracked by the CDC shows that Covid-19 case rates among seniors were 83% lower in the first week of March than they were two months earlier, and death rates were about 96% lower, both steeper declines than in any another age group.

"Right now, as the weeks go by, we see more and more that not only are these vaccines efficacious but in the community they are extremely effective in preventing infection with SARS-CoV-2," Fauci said during a White House briefing on Wednesday.