The shooting occurred around 10 p.m. on Gomains Avenue, a few blocks from Chapel Hill Town Hall, town police said.
A 31-year-old man suffered life-threatening injuries, police said. A teenaged male was also taken to a local hospital with non-life-threatening injuries.
Chapel Hill police said they had not made any arrests in the shooting early Thursday. They withheld the victims' names while they investigated the incident.
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