Chronology Of Events Regarding Jesica Santillan Transplant Attempts
Posted February 22, 2003
DURHAM, N.C. — CHRONOLOGY OF EVENTS REGARDING JESICA SANTILLAN
Evening of Feb. 6, 2003
Carolina Donor Services makes initial offer of a transplantable heart to Duke University Hospital.
February 7, 2003
The procuring team, including a Duke University Hospital surgeon, traveled to the hospital where the donor was located. The procuring surgeon examined the organs and judged them to be of good quality. He called Dr. Jaggers and was directed to procure the heart and lungs.
The organs were transported back to Duke University Hospital following a delay due to bad weather.
While the organ procurement team was traveling, Jesica Santillan was admitted to Duke University Hospital's pediatric intensive care unit.
Organ transplantation operation begins at about 4:50 p.m.
Once the organs arrived at Duke Hospital, the recipient's heart and lungs were removed, and the donor organs were implanted.
Following implantation of the organs (approximately 10 p.m.), the surgical team received a call from Duke's Clinical Transplant Immunology Laboratory reporting the organs were incompatible with Jesica's blood type.
Initiation of plasmapheresis and high dose immunosuppressants were begun in an effort to prevent organ rejection.
Jesica was transferred to PICU on conventional support, which included mechanical ventilation.
After surgery, Dr. Jaggers immediately informed the family and their supporters about the mistake in blood type matching.
Duke immediately notified United Network for Organ Sharing about the ABO incompatibility and the need for new organs for Jesica.
February 8-9, 2003
Jesica continued to receive aggressive therapy for the treatment of organ rejection, including plasmapheresis and the administration of high dose immunosuppressants.
February 10, 2003
In the morning, Jesica was removed from mechanical ventilation.
Over the course of the afternoon, her lung function deteriorated, and mechanical ventilation was resumed.
Lung function continued to decline, and ECMO support was initiated.
February 11-18, 2003
Medical therapies continued during the search for new organs.
February 19, 2003
In consultation with a neurologist, a CT scan was performed to evaluate the brain. Findings did not imply irreversible brain damage.
In the evening, heart and lungs of the same blood type as Jessica were offered to Dr. Jaggers, and he accepted them for Jesica.
The Duke transplant coordinator confirmed the blood type compatibility with Dr. Jaggers and then subsequently with the CDS coordinator.
February 20, 2003
Shortly after midnight, Dr. Jaggers discussed the possible second heart-lung transplant with Jesica's family and supporters who wished to proceed with the transplant.
Dr. Jaggers received confirmation from the procuring Duke surgical team of organ acceptability and blood group compatibility.
Jesica's heart and lungs were functioning acceptably. There was no evidence that her neurologic status or other bodily functions had changed.
February 21, 2003
February 22, 2003
Note: Life support was continued throughout the afternoon so that family and friends could say good-bye. Medications for the heart were discontinued at 5 p.m., and her heart rate began to slow. Her heart stopped at 5:07 p.m., and ventilator support was then discontinued at 5:10 p.m.