Police spotted a 1989 cream-colored Nissan Maxima connected to an armed robbery and aggravated assault that occurred within the past two weeks. Officers said they gave pursuit when the driver, Benjamin Wayne White Jr., 24, refused to stop.
The Maxima went through the intersection of Horton and Guess roads and struck a 2004 Toyota Avalon at 7:49 p.m.
Police said the chase lasted about eight minutes.
The occupants of the Avalon, a 63-year-old husband and 62-year-old wife, suffered non-life-threatening injuries and were taken to Duke University Hospital.
White; Rory Arrington Jr., 23; and a female occupant of the Maxima were also taken to Duke with non-life-threatening injuries.
White was charged with two counts of felony fleeing to elude, two counts of driving with a revoked license, two counts of careless and reckless driving and one count of possession of a firearm by a convicted felon.
Arrington faces one charge of possession of a firearm by a convicted felon. No charges have been filed against the woman who was in the Maxima.
Police said additional charges may be pending.
Arrington served 20 months on a charge of assault with a deadly weapon inflicting serious injury stemming from an incident in Durham County on Dec. 6, 2002, according to state Department of Corrections records.
Both White and Arrington have a record of convictions on charges related to drugs and stolen good charges going back to 2001 in Durham County.
