Oral Low Dose Intermittent Methotrexate as Steroid-Sparing Agent for Treatment of Canine Atopic Dermatitis-a Pilot Study

Description: A pilot study is being conducted to determine whether the addition of low doses of generic methotrexate will allow prednisone dose reduction in dogs with atopic dermatitis without adding unnecessary side effects. Methotrexate is a cheap generic drug whose effect has been shown to be beneficial in anecdotal cases at NC State. Diagnosis of canine atopic dermatitis, at least mild severity, based on standard methods and no evidence of clinically-relevant infections would be required to participate.

Eligibility: Dogs of any breed, gender, and age, weighing 7-50kgs with evidence of IgE reactivity against allergens by intradermal or serological tests. No complete response to a restriction-provocation dietary challenge (“elimination diet”)

Financial Incentive: There is no financial incentive for participation

Contact: Dermatology Service - Drs Thierry Olivry, Marcy Murphy, and Petra Bizikova 919.513.6691