People who need new organs can take hope after a Colombian woman underwent a successful transplant of a new windpipe grown from her own stem cells.
Spanish, British and Italian scientists invented the method that has let Claudia Castillo, a 30-year-old mother of two living in Barcelona, Spain, breath easy again.
A few months ago, she couldn't push her daughter on a swing without running out of breath.
"It was very hard to have conversations with my family," Castillo said, through a translator. "I had to tell them, 'Now, please, don't talk, because I need to breath.'"
Castillo had suffered from tuberculosis for years, and when her left lung collapsed in March, doctors thought the only solution was to remove it. But Dr. Paolo Macchiarini, head of thoracic surgery at Barcelona's Hospital Clinic, proposed a windpipe transplant instead.
In a revolutionary transplant, doctors gave Claudia a new windpipe with tissue grown from her own stem cells.
"This is a landmark in stem-cell biology, because we can say very clearly that we've turned stem-cell biology into stem-cell medicine," Dr. Anthony Hollander, a professor at the University of Bristol, in England, said.
Scientists at Italy's University of Padua stripped off all the cells of a donor windpipe, leaving only a tube of connective tissue. Meanwhile, doctors at the University of Bristol used stem cells from Castillo's bone marrow to create millions of cartilage and tissue cells.
Experts at the University of Milan used a device to put the new cartilage and tissue onto the windpipe. Castillo got the new organ in June and didn't have to take anti-rejection medicine since the new tissue came from her own stem cells.
Doctors said the effort opens the door for all kinds of transplants: "new bowels, new bladders, new blood vessels," said Dr. Martin Birchall, of the University of Bristol.
"It's a very small leap, having shown that we can do it and it's safe to do," Birchall said.
The doctors behind the surgery said they are planning future trachea transplants based on Castillo's success.
"As long as she stays in this health, I will be the happiest doctor in the world," Macchiarini said.





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Which means the scientific community has had its hands tied by the Bush administration. Without public funding, universities CANNOT do hES cell work. It amazes me that people argue against ES cell funding by saying the "biggest breakthroughs" have been with adult stem cells. Well of course they have! We're allowed to do research with them! Big breakthroughs will happen with ES cells too once we can study them...AND this will lead to better understanding adult stem cells too.
November 26, 2008 7:22 p.m.
Research is allowed on embryonic stem cells, it's just not funded by the federal government...scratch that...your pocket!
November 25, 2008 6:12 p.m.
kurt, you do know that one of the main sources of embryonic stem cells are fertility clinics where couples go for help with conception? And, the "extra" embryonic material is destroyed and discarded as part of this process anyway. And, this material could be used for scientific research instead, if it had been allowed. Just sayin', since you made such a blanket statement.
November 25, 2008 4:45 p.m.
President Bush merely decided to continue along with the spirit of this legislation rather than find ways around it. He didn't "pull funding."
To date, most promising stem cell research revolves around adult stem cells & cord blood, which carry none of the ethical concerns of embryonic stem cell research. This is what the Dickey Amendment was written to address.
Throughout history the excuse of "Everyone else is doing it!" has never been a good one.
November 25, 2008 4:37 p.m.
November 25, 2008 3:33 p.m.