Health Team

Newer antipsychotic drugs come with their own new side effects

Posted September 15, 2008
Updated September 16, 2008

— Newer drugs aren't necessarily better for young patients with severe mental illness – especially with the side effect of weight gain.

University of North Carolina professors hope their research into the positive and negative effects of such drugs will benefit teenagers with schizophrenia.

Brandon Constantineau, 18, of Wilmington, suffered severe mental illness as early as elementary school. Then, he started experiencing regular hallucinations.

"I had this friend in school who wasn't even real," Constantineau said.

His mother, Darlene Wilson, said she began to realize that more was going on than an over-active imagination.

"Sometimes, he would hear voices that weren't there or see things that weren't there," Wilson said.

That problem, along with extreme mood swings and emotional outbursts, got worse as Constantineau grew older. He was 15 when Dr. Lin Sikich, a psychiatrist with UNC, diagnosed him as suffering from  schizophrenia.

Constantineau joined a study to compare two newer drugs – Zyprexa, or olanzapine, and Risperdal, or risperidone – with an older one – Moban, or molindone.

All of the medications limit the amount of dopamine in the brain, which causes the psychotic symptoms.

"There wasn't a clear frontline drug to use," Sikich said. "All the drugs worked about equally well."

Constantineau was randomly assigned to Zyprexa. That drug and Risperdal caused him and other young patients to gain weight at an alarming rate.

"In a few short months, he had gained almost 35 pounds," Wilson said.

"It affected me greatly, because the kids were starting to notice I was gaining weight. I was getting picked on," Constantineau said.

Long term, that weight gain could cause life-threatening problems, such as heart disease and diabetes. In many patients, it can also exacerbate feelings of depression.

Sikich took Constantineau out of the study and changed his prescription. He takes Geodon, another newer-line drug, and glucophage, a diabetic drug used to control weight.

Constantineau said those drugs are helping him to better enjoy life with friends and family and to function at school.

"The medicine I'm on currently helps me out. It keeps the balance," Constantineau said.

Newer antipsychotic drugs do a good job at controlling symptoms, such as hallucinations, delusions and paranoia, but are less effective in dealing with apathy and problem-solving ability.

"The medicines do help, but we have to be really careful about the side effects," Sikich said.


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  • See Chart Sep 15, 2008

    Why do we still seek the advice carte blance
    from Psychiatrists without doing our own research
    as to possible dangerous side effects to our kids?

    One has to look into the effect of food allergies in
    certain childhood illness before taking these new or old
    psycho pharmacological medicines amongst other missed causes
    by our overworked Physicians.

  • BruiserB Sep 15, 2008

    Our daughter, who was brain injured at birth, was on Risperadol (sp). Her weight ballooned like crazy. When she was taken off it, she dropped over eighty pounds. It's too easy for doctors to prescribe drugs without really listening to the patient/parents or looking at patient history. I was recently prescribed Cialis even though I'm on heart meds and have a condition known as atrial tachycardia and the doctor knew I had this condition. Really, Cialis ? No I didn't take it.

  • DannyHaszard Sep 15, 2008

    Lilly Zyprexa ' Chemical Straitjacket' Use by Children.

    Zyprexa,as well as the other atypical antipsychotics, are being prescribed for children, even though this is an unapproved, off-label use. Eli Lilly has been charged in allegedly pushing the drug for children in more than one state.

    A report by Dr. Cooper at Vanderbilt University states that 2.5 million children are now taking atypical antipsychotics.

    St. Petersburg Times Reports on Zyprexa A risky drug may get wider marketThe FDA may approve Zyprexa for kids, despite its significant side effects in adult use.

    Daniel Haszard Zyprexa patient who got diabetes from it.