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Health Team

Human Gene Variants Could Be Key to Fighting AIDS

Posted July 19, 2007

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— An international team of researchers has identified three gene variants in the DNA of 486 people infected with HIV that appear to have helped some of the patients fight off the virus and delay the onset of full-blown AIDS.

The researchers expect the new findings to aid the search for an HIV vaccine that would work by boosting the protective effects of one or more of these genes, and help the body's own immune system overcome an infection. One of the genes looks particularly attractive as a vaccine target.

The study, published early online by the journal Science July 19, was directed by David Goldstein, Ph.D., at Duke University and is the first large cooperative study with major findings arising from the Center for HIV/AIDS Vaccine Immunology, (CHAVI) a seven-year project funded by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, in 2005, led by Duke's Barton Haynes, M.D.

It took the international genetics team, called EuroCHAVI, pooling their cohorts of carefully selected patients and using the latest in genome-wide screening technology, 18 months to discover the three genes, that together greatly increase our knowledge of why patients differ in how well they can control the virus that causes AIDS.

These findings represent only the first of what investigators said will be a series of future genome-wide studies to pinpoint additional targets for HIV vaccines. In the new analysis, patients with specific gene variants in key immune system cells appear to be much better at controlling the proliferation of the virus after infection. These gene variants are known as polymorphisms.

7 Comments

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  • papa jim Jul 21, 2007

    one thing that would help fight the spread of aid is to KEEP IT IN YOUR JEANS

  • Ripcord Jul 21, 2007

    AIDS could be virtually eliminated if people simply changed their behavior.

  • hollylama Jul 20, 2007

    The way to find a vaccine is to investigate a population that’s been exposed and does NOT have the virus but unfortunately determining who’s been exposed is the difficulty. Rather than do that these investigators look at individuals with the virus, try to determine how long the individual has had the virus and then look at the viral loads to determine what genetic factors may be inhibiting or replicating the virus.

  • normalthinking Jul 20, 2007

    the way to find a vaccine is to study the people who are exposed but DONT get the virus

  • sjmr1216 Jul 20, 2007

    "hurry up and find a vaccine"? they have been searching for a vaccine for years. it's tough to fight something that mutates so much and so quickly

  • ECU Alumni 06 Jul 20, 2007

    Everyone must be careful dating these days. Too many things happens.

  • lishaxlisha Jul 20, 2007

    WOW!They need to hurry up and fine a Vaccine for this disease, cause I'm scared to date anyone now a days, you can't tell who got it and who doesn't.